CRISPulator
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A pooled genetic screen simulator
Crispulator does not yet support Julia 1.0! We're still waiting on all the dependencies to be updated, please use Julia v0.6.4 in the mean time.
Motivation
Pooled screens are very useful, but they are also extraordinarily complex. This work aims to explore the importance of various screen parameters and the relevance of design choices on the downstream analysis and interpretation.
Paper
Nagy, T. & Kampmann, M. CRISPulator: a discrete simulation tool for pooled genetic screens. BMC Bioinformatics 18, 347 (2017). https://doi.org/10.1186/s12859-017-1759-9 (Preprint also available)